How It WorksOur expertise is next generation portable medical diagnostics
The chips combine microfluidic functional elements: blood filters, sample collectors, valves, channels, reaction chambers and pumps.
We integrate biochemical reagents directly on the microfluidic chips. We dramatically miniaturize biochemical reactions preserving valuable samples and reagents, increasing the sensitivity of tests, accelerating mass transport limited reactions, leading to a faster time to high quality results.
Alternative approaches require several reagents and sample manipulation steps and are therefore confined to the laboratory or the physician’s back office.
In contrast, our microfluidic chips include all reagents and processing steps on-chip and detection of biomarkers can be done at the patient’s side by simply adding sample to the chips.
1Drop portable medical diagnostics is robust, multiplexing, easy to use, and affordable. We strongly confine electromagnetic fields to the surface by coupling to propagating or localized surface plasmons.
We shorten detection times and increase sensitivity of fluorescence assays.
We are working towards defining the future of technology enabled medical diagnostics and corresponding care delivery. Our portable medical diagnostics provide real patient perspectives, clinical applications and outcomes based results.
We leverage technology that is already in patients’ and healthcare providers’ hands, such as mobile phones. We provide solutions that deliver rapid results and self-management tools across a broad spectrum of care.
We create novel patient-centered medical diagnostics that enhance clinical care, and integrate health and wellness into the lives of patients. We design and fabricate diagnostic devices that support chronic disease management, increase adherence and inspire healthy behavior.
Journals Featuring Our Work
1DROP Diagnostics In Scientific Journals
“Connecting μ-fluidics to electron microscopy”
“Controlled release of reagents in capillary-driven microfluidics”
“Capillary-driven multiparametric microfluidic chips for one- step immunoassays”
“Microfluidic chips for point-of-care immunodiagnostics”
“Fabrication of large scale arrays of metallic nanodots by means of high resolution e-beam lithography”
“Toward one-step point-of-care immunodiagnostics using capillary-driven microfluidics and PDMS substrates”
“Replication of high aspect ratio pillar array structures in biocompatible polymers for tissue engineering applications”
“High-performance immunoassays based on through-stencil patterned antibodies and capillary systems”
“Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer”
Authors: S. Kemmerling, J. Ziegler, G. Schweighauser, S. A. Arnold, D. Giss, S. A. Müller, Philippe Ringler, K. N. Goldie, N. Goedecke, A. Hierlemann, H. Stahlberg, A. Engel, T. Braun
Journal of Structural Biology, 2012
Authors: M. Hitzbleck, L. Gervais, E. Delamarche
Lab on a Chip, 2011
Authors: L. Gervais, M. Hitzbleck, E. Delamarche
Biosensors and Bioelectronics, 2011
Authors: L. Gervais, N. de Rooij, E. Delamarche
Advanced Materials (cover article), 2011
Authors: V. A. Guzenko, J. Ziegler, A. Savouchkina, C. Padeste, and C. David
Microelectronic Engineering, 2011
Authors: C. Padeste, H. Özçelik, J. Ziegler, A. Schleunitz, M. Bednarzik, D. Yücel, V. Hasirci
Microelectronic Engineering, 2011
Authors: L. Gervais and E. Delamarche
Lab on a Chip (cover article), 2009
Authors: J. Ziegler, M. Zimmermann, P. Hunziker, E. Delamarche
Analytical Chemistry, 2008
Authors: Broz P, Driamov S, J. Ziegler , Ben-Haim N, Meier W, and Hunziker
Nano Letters, 2006